Botswana: Study finds low concentrations of TB drugs common in HIV-positives

A pharmacokinetic (PK) study conducted in people on directly observed tuberculosis (TB) treatment in Botswana calls into question whether the standard TB drug dosing is really adequate for all populations, particularly among people with advanced HIV living in sub-Saharan Africa. The study, which was presented at the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention in Sydney, Australia, found that low concentrations of TB drugs were common in the population, regardless of HIV status.